SCHEMBL12462230

SCHEMBL12462230

Cc1cc(=O)nc(NC(=O)NCCCCNC(=O)OC(C)(C)C)[nH]1

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ CCNC P24863 1/20 0.45
▸ CDK8 P49336 1/20 0.45
▸ TDP1 Q9NUW8 1/20 0.43
▸ BCHE P06276 1/20 0.42
▸ BRD4 O60885 7/20 0.40
▸ STK17B O94768 1/20 0.39
▸ STK17A Q9UEE5 1/20 0.39
▸ MAOA P21397 1/20 0.39
▸ MAOB P27338 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ GAA P10253 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ CA12 O43570 1/20 0.38
▸ CA1 P00915 1/20 0.38
▸ CA2 P00918 1/20 0.38
▸ CA9 Q16790 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27047926 0.98 TDP1 (0.44) CCNCCDK8TDP1BCHEBRD4
SCHEMBL12462274 0.90 BCHE (0.40) CCNCCDK8BCHESTK17BSTK17A
SCHEMBL21065264 0.86 TDP1 (0.43) TDP1MEN1GAAKMT2ACA1
SCHEMBL21065266 0.86 TDP1 (0.43) TDP1MEN1GAAKMT2ACA1
SCHEMBL12462647 0.86 TDP1 (0.52) TDP1MEN1GAAKMT2A
SCHEMBL14577308 0.85 CCNC (0.37) CCNCCDK8TDP1BCHEBRD4
SCHEMBL13684302 0.84 ABL1 (0.38) MEN1GAAKMT2A
SCHEMBL19254473 0.84 EPHX2 (0.38) BRD4GAA
SCHEMBL15119390 0.84 ACHE (0.42) BCHE
SCHEMBL13997007 0.83 EPHX1 (0.45) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11141368-B2 Cosmetic composition, cosmetic treatment method, kit, and compound L'OREAL (FR) 2021-10-12 — — US disclosed
US-10813866-B2 Cosmetic composition, cosmetic treatment method, kit, and compound L'OREAL (FR) 2020-10-27 — — US disclosed
EP-2521530-B1 COSMETIC COMPOSITION, COSMETIC TREATMENT METHOD, KIT, AND COMPOUND OREAL (FR) 2019-06-26 — — EP disclosed
US-9561165-B2 Cosmetic treatment processes and kit L'OREAL (FR) 2017-02-07 — — US disclosed
US-9561165-B2 Cosmetic treatment processes and kit L'OREAL (FR) 2017-02-07 — — US disclosed
US-9089500-B2 Cosmetic treatment processes and kit L'OREAL (FR) 2015-07-28 — — US disclosed
US-9089500-B2 Cosmetic treatment processes and kit L'OREAL (FR) 2015-07-28 — — US disclosed
CN-104185469-A Cosmetic treatment processes and kit OREAL 2014-12-03 — — CN disclosed
US-20140155352-A1 COSMETIC TREATMENT PROCESSES AND KIT L'OREAL (FR) 2014-06-05 — — US disclosed
US-20140155352-A1 COSMETIC TREATMENT PROCESSES AND KIT L'OREAL (FR) 2014-06-05 — — US disclosed
US-20130017162-A1 COSMETIC COMPOSITION, COSMETIC TREATMENT METHOD, KIT, AND COMPOUND L'OREAL (FR) 2013-01-17 — — US disclosed
US-20130017162-A1 COSMETIC COMPOSITION, COSMETIC TREATMENT METHOD, KIT, AND COMPOUND L'OREAL (FR) 2013-01-17 — — US disclosed
WO-2013004982-A2 COSMETIC TREATMENT PROCESSES AND KIT L'OREAL (FR) 2013-01-10 — — WO disclosed
WO-2011083243-A1 COSMETIC TREATMENT METHODS AND KIT L'OREAL (FR) 2011-07-14 — — WO disclosed
WO-2011080494-A2 COSMETIC COMPOSITION, COSMETIC TREATMENT METHOD, KIT, AND COMPOUND L'OREAL (FR) 2011-07-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140155352-A1 COSMETIC TREATMENT PROCESSES AND KIT KIT, KRT18, MKI67 CCNC 932/4885CDK8 1536/4885TDP1 1675/4885
US-20130017162-A1 COSMETIC COMPOSITION, COSMETIC TREATMENT METHOD, KIT, AND COMPOUND KRT18, KIT, TYR CCNC 570/4885CDK8 2358/4885TDP1 4164/4885
US-10813866-B2 Cosmetic composition, cosmetic treatment method, kit, and compound KRT18, KIT, TYR CCNC 570/4885CDK8 2358/4885TDP1 4164/4885
US-11141368-B2 Cosmetic composition, cosmetic treatment method, kit, and compound KRT18, KIT, TYR CCNC 570/4885CDK8 2358/4885TDP1 4164/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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