Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1247390 | 1.00 | SCN9A (0.44) | SCN9ASCN5AMAPTNTRK1NPSR1 | |
| SCHEMBL1246475 | 0.91 | SCN9A (0.41) | SCN9ASCN5AMAPTNTRK1NPSR1 | |
| SCHEMBL1245118 | 0.90 | SCN9A (0.55) | SCN9ASCN5AMAPTNTRK1NPSR1 | |
| SCHEMBL1247241 | 0.90 | SCN9A (0.55) | SCN9ASCN5AMAPTNTRK1NPSR1 | |
| SCHEMBL2337612 | 0.86 | LPAR1 (0.51) | SCN9ASCN5AMAPTPTGS2FAAH | |
| SCHEMBL2341082 | 0.86 | LPAR1 (0.51) | SCN9ASCN5AMAPTPTGS2FAAH | |
| SCHEMBL1245272 | 0.86 | SCN9A (0.45) | SCN9ASCN5AMAPTNTRK1NPSR1 | |
| SCHEMBL1245064 | 0.85 | SCN9A (0.48) | SCN9ASCN5AMAPTNTRK1NPSR1 | |
| SCHEMBL1246321 | 0.84 | NTRK1 (0.45) | SCN9ASCN5AMAPTNTRK1NPSR1 | |
| SCHEMBL1245151 | 0.82 | SCN9A (0.55) | SCN9ASCN5AMAPTNTRK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |