Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | FABP2 | P12104 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1246243 | 0.91 | SCN9A (0.44) | SCN9ASCN5APTGS2FAAHMAPT | |
| SCHEMBL1247390 | 0.91 | SCN9A (0.44) | SCN9ASCN5APTGS2FAAHMAPT | |
| SCHEMBL2338472 | 0.88 | LPAR1 (0.44) | AKR1C3AKR1C2PTGS2FAAHPTGS1 | |
| SCHEMBL1247167 | 0.85 | SCN9A (0.43) | SCN9ASCN5AMEN1KMT2AMAPT | |
| SCHEMBL11895802 | 0.83 | LPAR1 (0.42) | SCN9ASCN5AAKR1C3AKR1C2PTGS2 | |
| SCHEMBL11895801 | 0.83 | LPAR1 (0.42) | SCN9ASCN5AAKR1C3AKR1C2PTGS2 | |
| SCHEMBL1247241 | 0.82 | SCN9A (0.55) | SCN9ASCN5APTGS2MAPTNTRK1 | |
| SCHEMBL1245118 | 0.82 | SCN9A (0.55) | SCN9ASCN5APTGS2MAPTNTRK1 | |
| SCHEMBL2338258 | 0.81 | LPAR1 (0.41) | SCN9ASCN5APTGS2FAAHMEN1 | |
| SCHEMBL2337612 | 0.80 | LPAR1 (0.51) | SCN9ASCN5AAKR1C3AKR1C2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |