Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 2/20 | 0.33 |
| ▸ | TKT | P29401 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16023759 | 0.79 | TRPV4 (0.52) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 | |
| SCHEMBL19879960 | 0.79 | TRPV4 (0.52) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 | |
| SCHEMBL30406321 | 0.75 | TRPV4 (0.47) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 | |
| SCHEMBL16014037 | 0.75 | TRPV4 (0.47) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 | |
| SCHEMBL3564553 | 0.75 | TRPV4 (0.47) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 | |
| SCHEMBL17366564 | 0.72 | TRPV4 (0.44) | TRPV4PIK3CAPI4KBPIK3CDPIK3CB | |
| SCHEMBL114542 | 0.71 | TRPV4 (0.58) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 | |
| SCHEMBL130934 | 0.71 | TRPV4 (0.58) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 | |
| SCHEMBL29421253 | 0.71 | TRPV4 (0.58) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 | |
| SCHEMBL29497498 | 0.71 | TRPV4 (0.58) | TRPV4KCNH2PIK3CAPI4KBMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011014520-A2 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2011-02-03 | — | — | WO | claimed |
| WO-2011014520-A2 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2011-02-03 | — | — | WO | disclosed |