Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.33 |
| ▸ | MTOR | P42345 | 3/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.31 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14725941 | 0.84 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1GAAPOLBPIK3CA | |
| SCHEMBL12462791 | 0.79 | ALDH1A1 (0.39) | ALDH1A1GAAPOLBPIK3CAPIK3R1 | |
| SCHEMBL12462793 | 0.75 | PDE4A (0.36) | ALDH1A1GAAPOLBPIK3CAPIK3R1 | |
| SCHEMBL14725985 | 0.68 | KDM4E (0.43) | ALDH1A1L3MBTL1POLBKDM4EMEN1 | |
| SCHEMBL13896917 | 0.65 | PIK3CA (0.45) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL12463396 | 0.64 | POLB (0.39) | ALDH1A1GAAPOLBPIK3CAPIK3R1 | |
| SCHEMBL14149150 | 0.63 | KDM4E (0.63) | ALDH1A1GAAPOLBKDM4EMEN1 | |
| SCHEMBL5561919 | 0.62 | HTR2C (0.39) | ALDH1A1L3MBTL1GAAPOLBPIK3CA | |
| SCHEMBL14725935 | 0.62 | ALDH1A1 (0.39) | ALDH1A1POLBPIK3CAPIK3R1KDM4E | |
| SCHEMBL26071904 | 0.61 | KDM4E (0.39) | ALDH1A1L3MBTL1POLBPIK3CAPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011089400-A1 | INHIBITORS OF PI3 KINASE | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2011-07-28 | — | — | WO | disclosed |