Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 18/20 | 0.74 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12463249 | 0.91 | MTOR (0.73) | MTOR | |
| SCHEMBL13718693 | 0.85 | MTOR (1.00) | MTOR | |
| SCHEMBL12463245 | 0.83 | MTOR (0.53) | MTOREPHX2 | |
| SCHEMBL12463247 | 0.82 | MTOR (0.50) | MTOR | |
| SCHEMBL12463152 | 0.82 | MTOR (0.71) | MTOR | |
| SCHEMBL12463001 | 0.81 | MTOR (0.55) | MTOR | |
| SCHEMBL12463246 | 0.81 | MTOR (0.54) | MTOR | |
| SCHEMBL13718871 | 0.76 | MTOR (1.00) | MTOR | |
| SCHEMBL13718467 | 0.75 | MTOR (1.00) | MTOR | |
| SCHEMBL12463443 | 0.74 | MTOR (0.78) | MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011080568-A2 | NOVEL PYRIMIDINE COMPOUNDS AS MTOR AND P13K INHIBITORS | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2011-07-07 | — | — | WO | disclosed |