Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19762742 | 0.86 | MAPK1 (0.51) | MAPK1POLBMEN1KMT2ACES1 | |
| SCHEMBL11811932 | 0.85 | MAPT (0.54) | MAPK1POLBMEN1KMT2ACES1 | |
| SCHEMBL17948714 | 0.81 | POLB (0.54) | MAPK1POLBMEN1KMT2ACES1 | |
| SCHEMBL1738 | 0.79 | MAPT (0.43) | MAPK1MEN1KMT2ACES1MAPT | |
| SCHEMBL28780782 | 0.78 | KMT2A (0.50) | KMT2ACES1LMNATDP1ALDH1A1 | |
| SCHEMBL28689257 | 0.78 | MAPT (0.53) | MAPK1POLBMEN1KMT2ACES1 | |
| SCHEMBL2874789 | 0.77 | SLC6A3 (0.52) | MAPK1POLBMEN1KMT2AMAPT | |
| SCHEMBL27490020 | 0.77 | MAPK1 (0.61) | MAPK1MEN1KMT2ACES1MAPT | |
| SCHEMBL13172626 | 0.76 | NPC1 (0.50) | MAPK1POLBMEN1KMT2AMAPT | |
| SCHEMBL3703967 | 0.75 | CA1 (0.43) | MAPK1POLBMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785442-B2 | Compound as antagonist of lysophosphatidic acid receptor, composition, and use thereof | CUREGENIX, INC. (CN) | 2014-07-22 | — | — | US | disclosed |
| US-8785442-B2 | Compound as antagonist of lysophosphatidic acid receptor, composition, and use thereof | CUREGENIX, INC. (CN) | 2014-07-22 | — | — | US | disclosed |
| US-8785442-B2 | Compound as antagonist of lysophosphatidic acid receptor, composition, and use thereof | CUREGENIX, INC. (CN) | 2014-07-22 | — | — | US | disclosed |
| US-20140031353-A1 | COMPOUND AS ANTAGONIST OF LYSOPHOSPHATIDIC ACID RECEPTOR, COMPOSITION, AND USE THEREOF | CUREGENIX, INC. (CN) | 2014-01-30 | — | — | US | disclosed |
| US-20140031353-A1 | COMPOUND AS ANTAGONIST OF LYSOPHOSPHATIDIC ACID RECEPTOR, COMPOSITION, AND USE THEREOF | CUREGENIX, INC. (CN) | 2014-01-30 | — | — | US | disclosed |
| US-20140031353-A1 | COMPOUND AS ANTAGONIST OF LYSOPHOSPHATIDIC ACID RECEPTOR, COMPOSITION, AND USE THEREOF | CUREGENIX, INC. (CN) | 2014-01-30 | — | — | US | disclosed |
| WO-2012100436-A1 | COMPOUND AS ANTAGONIST OF LYSOPHOSPHATIDIC ACID RECEPTOR, COMPOSITION, AND USE THEREOF | CUREGENIX INC. (CN) | 2012-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031353-A1 | COMPOUND AS ANTAGONIST OF LYSOPHOSPHATIDIC ACID RECEPTOR, COMPOSITION, AND USE THEREOF | LPAR1, LPAR2, LPAR5 | MAPK1 2366/4885POLB 4225/4885MEN1 1722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.