Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 3/20 | 0.45 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.45 |
| ▸ | RARA | P10276 | 4/20 | 0.43 |
| ▸ | RARB | P10826 | 4/20 | 0.43 |
| ▸ | RARG | P13631 | 4/20 | 0.43 |
| ▸ | RXRA | P19793 | 3/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.40 |
| ▸ | HNF4A | P41235 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12465708 | 0.81 | SSTR5 (0.40) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL8773454 | 0.76 | CYP26A1 (0.49) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL12465596 | 0.75 | MME (0.41) | TAS1R3TAS1R1HSD17B10MMEHPGD | |
| SCHEMBL6146899 | 0.74 | CYP26A1 (0.69) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL10959891 | 0.73 | CYP26A1 (0.46) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL2246604 | 0.73 | CYP26A1 (0.51) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL12465974 | 0.73 | NOTUM (0.33) | MME | |
| SCHEMBL3998188 | 0.71 | CYP26A1 (0.49) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL12348759 | 0.70 | CYP26A1 (0.48) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL2243072 | 0.70 | CYP26A1 (0.48) | CYP26A1CYP26B1RARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670744-A1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | Lupin Limited (IN) | 2013-12-11 | — | — | EP | disclosed |
| WO-2012104782-A1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | LUPIN LIMITED (IN) | 2012-08-09 | — | — | WO | disclosed |