Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 4/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 3/20 | 0.31 |
| ▸ | RARA | P10276 | 1/20 | 0.31 |
| ▸ | RARB | P10826 | 1/20 | 0.31 |
| ▸ | RARG | P13631 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.30 |
| ▸ | RXRG | P48443 | 1/20 | 0.30 |
| ▸ | HNF4A | P41235 | 2/20 | 0.30 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.30 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12465704 | 0.81 | CYP26A1 (0.45) | SSTR5RXRARARARARBRARG | |
| SCHEMBL12468551 | 0.68 | PTGS2 (0.40) | SSTR5PTGS1PTGS2RXRARARA | |
| SCHEMBL12465698 | 0.66 | PTGS2 (0.46) | SSTR5PTGS1PTGS2RXRARARA | |
| SCHEMBL12465974 | 0.65 | NOTUM (0.33) | — | |
| SCHEMBL12465596 | 0.63 | MME (0.41) | TAS1R3TAS1R1 | |
| SCHEMBL12465699 | 0.61 | SSTR5 (0.33) | SSTR5PTGS1PTGS2 | |
| SCHEMBL15002369 | 0.61 | PTGS1 (0.35) | SSTR5PTGS1PTGS2RXRAHNF4A | |
| SCHEMBL7196161 | 0.60 | SSTR5 (0.38) | SSTR5PTGS1PTGS2RXRARARA | |
| SCHEMBL9766489 | 0.60 | HDAC1 (0.60) | — | |
| SCHEMBL12465678 | 0.59 | SSTR5 (0.33) | SSTR5RARARARBRARGHNF4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670744-A1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | Lupin Limited (IN) | 2013-12-11 | — | — | EP | disclosed |
| WO-2012104782-A1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | LUPIN LIMITED (IN) | 2012-08-09 | — | — | WO | disclosed |