SCHEMBL12465808

SCHEMBL12465808

CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(-c3cccc(F)c3)cs2)cc1

nearest known ligand 0.78

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
RORC P51449 20/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12465719 0.88 RORC (0.69) RORC
SCHEMBL12466032 0.88 RORC (0.78) RORC
SCHEMBL12465791 0.88 RORC (1.00) RORC
SCHEMBL12465767 0.88 RORC (0.78) RORC
SCHEMBL12465863 0.87 RORC (0.74) RORC
SCHEMBL12465749 0.85 RORC (0.76) RORC
SCHEMBL12465727 0.83 RORC (0.67) RORC
SCHEMBL12465751 0.82 RORC (0.69) RORC
SCHEMBL12465776 0.82 RORC (0.79) RORC
SCHEMBL18961577 0.80 RORC (0.68) RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012100732-A1 RETINOID-RELATED ORPHAN RECEPTOR GAMMA MODULATORS, COMPOSITION CONTAINING THEM AND USES THEREOF GLAXO GROUP LIMITED (GB) 2012-08-02 WO disclosed