Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 17/20 | 0.85 |
| ▸ | CDK9 | P50750 | 15/20 | 0.85 |
| ▸ | CCNK | O75909 | 5/20 | 0.85 |
| ▸ | CDK14 | O94921 | 2/20 | 0.85 |
| ▸ | CDK1 | P06493 | 2/20 | 0.85 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.85 |
| ▸ | CDK2 | P24941 | 2/20 | 0.85 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.85 |
| ▸ | CDK16 | Q00536 | 2/20 | 0.85 |
| ▸ | CDK17 | Q00537 | 1/20 | 0.85 |
| ▸ | CDK18 | Q07002 | 1/20 | 0.85 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.85 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | CCNH | P51946 | 1/20 | 0.49 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | CCNY | Q8ND76 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12465990 | 1.00 | CCNT1 (0.85) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL12465945 | 1.00 | CCNT1 (0.85) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL12465946 | 1.00 | CCNT1 (0.85) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL12465988 | 1.00 | CCNT1 (0.85) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL12465913 | 1.00 | CCNT1 (0.85) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL6119660 | 0.95 | CCNT1 (0.76) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL6119108 | 0.95 | CCNT1 (0.76) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL6119656 | 0.95 | CCNT1 (0.76) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL6119628 | 0.95 | CCNT1 (0.76) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL6119621 | 0.95 | CCNT1 (0.76) | CCNT1CDK9CCNKCDK14CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668162-A1 | SUBSTITUTED BI-HETEROARYL COMPOUNDS AS CDK9 INHIBITORS AND THEIR USES | Novartis AG (CH) | 2013-12-04 | — | — | EP | claimed |
| US-20130303507-A1 | SUBSTITUTED HETERO-BIARYL COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2013-11-14 | — | — | US | claimed |
| WO-2012101062-A1 | SUBSTITUTED BI-HETEROARYL COMPOUNDS AS CDK9 INHIBITORS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | claimed |
| EP-2668162-A1 | SUBSTITUTED BI-HETEROARYL COMPOUNDS AS CDK9 INHIBITORS AND THEIR USES | Novartis AG (CH) | 2013-12-04 | — | — | EP | disclosed |
| US-20130303507-A1 | SUBSTITUTED HETERO-BIARYL COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2013-11-14 | — | — | US | disclosed |
| WO-2012101066-A1 | PYRIDINE BIARYL AMINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012101065-A2 | PYRIMIDINE BIARYL AMINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012101062-A1 | SUBSTITUTED BI-HETEROARYL COMPOUNDS AS CDK9 INHIBITORS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303507-A1 | SUBSTITUTED HETERO-BIARYL COMPOUNDS AND THEIR USES | CDK9, CDK19, CDK3 | CCNT1 50/4885CDK9 1/4885CCNK 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.