Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 4/20 | 0.52 |
| ▸ | CDK7 | P50613 | 10/20 | 0.48 |
| ▸ | CDK9 | P50750 | 8/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.48 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.48 |
| ▸ | CCNH | P51946 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.47 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12466160 | 1.00 | CCNT1 (0.52) | CCNT1CDK7CDK9CSNK1A1CSNK1D | |
| SCHEMBL31334056 | 0.83 | CCNT1 (0.57) | CCNT1CDK7CDK9CSNK1A1CSNK1D | |
| SCHEMBL31334905 | 0.82 | CCNT1 (0.53) | CCNT1CDK7CDK9CSNK1A1CSNK1D | |
| SCHEMBL31334093 | 0.82 | CCNT1 (0.53) | CCNT1CDK7CDK9CSNK1A1CSNK1D | |
| SCHEMBL31334729 | 0.82 | CCNT1 (0.53) | CCNT1CDK7CDK9CSNK1A1CSNK1D | |
| SCHEMBL1192120 | 0.79 | CCNT1 (0.65) | CCNT1CDK7CDK9CSNK1A1CSNK1D | |
| SCHEMBL1192116 | 0.79 | CCNT1 (0.65) | CCNT1CDK7CDK9CSNK1A1CSNK1D | |
| SCHEMBL12466465 | 0.79 | CCNT1 (0.50) | CCNT1CDK7CDK9CSNK1A1CSNK1D | |
| SCHEMBL12466469 | 0.79 | CCNT1 (0.50) | CCNT1CDK7CDK9CSNK1A1CSNK1D | |
| SCHEMBL12465928 | 0.78 | CCNT1 (0.59) | CCNT1CDK7CDK9CSNK1A1CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012101065-A2 | PYRIMIDINE BIARYL AMINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |