Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.51 |
| ▸ | PTPRZ1 | P23471 | 2/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.37 |
| ▸ | KCNK2 | O95069 | 4/20 | 0.36 |
| ▸ | KCNK10 | P57789 | 3/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485396 | 0.84 | CXCR2 (0.53) | CXCR2PTPRZ1PTPN2PTPN1PTPN7 | |
| SCHEMBL485143 | 0.81 | CXCR2 (0.51) | CXCR2PTPRZ1PTPN2PTPN1PTPN7 | |
| SCHEMBL486231 | 0.79 | CXCR2 (0.52) | CXCR2SMN1; SMN2 | |
| SCHEMBL485624 | 0.79 | CXCR2 (0.72) | CXCR2PTPRZ1PTPN2PTPN1PTPN7 | |
| SCHEMBL485489 | 0.79 | CXCR2 (0.72) | CXCR2PTPRZ1KCNK2KCNK10NR1H4 | |
| Formic Acid SCHEMBL27693212 | 0.79 | CXCR2 (0.50) | CXCR2SMN1; SMN2 | |
| SCHEMBL27693210 | 0.78 | CXCR2 (0.57) | CXCR2PTPRZ1PTPN2PTPN1PTPN7 | |
| SCHEMBL484994 | 0.73 | CXCR2 (0.65) | CXCR2PTPRZ1PTPN2PTPN1PTPN7 | |
| SCHEMBL12468141 | 0.73 | CXCR2 (0.44) | CXCR2PPARDKDM4E | |
| SCHEMBL485586 | 0.71 | CXCR2 (0.62) | CXCR2PTPRZ1PTPN2PTPN1PTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8283479-B2 | CXCR2 inhibitors | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2012-10-09 | — | — | US | disclosed |
| US-20110184177-A1 | CXCR2 INHIBITORS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110184177-A1 | CXCR2 INHIBITORS | CXCR2, CXCR1, CXCR4 | CXCR2 1/4885PTPRZ1 786/4885PTPN2 151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.