Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1693676 | 0.77 | ADORA2A (0.56) | ADORA2AADORA1EPHB4 | |
| SCHEMBL794555 | 0.73 | ADORA2A (0.40) | ADORA2AADORA1PIK3CAMAPTSMN1; SMN2 | |
| SCHEMBL656145 | 0.64 | FGFR1 (0.56) | FGFR1EGFR | |
| SCHEMBL654609 | 0.61 | FGFR1 (0.47) | ADORA2AADORA1PIK3CAFGFR1KDM4E | |
| SCHEMBL653492 | 0.61 | CSNK2A1 (0.48) | FGFR1EGFR | |
| SCHEMBL655418 | 0.61 | PIK3CA (0.45) | ADORA2AADORA1PIK3CAFGFR1KDM4E | |
| SCHEMBL13126260 | 0.60 | SLC6A2 (0.48) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL656557 | 0.60 | FGFR1 (0.69) | FGFR1EGFR | |
| SCHEMBL16953382 | 0.59 | SLC6A2 (0.43) | KDM4ENPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL27472082 | 0.59 | SLC6A2 (0.40) | KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616077-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2013-07-24 | — | — | EP | disclosed |
| EP-2575969-A1 | ANTIVIRAL ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2013-04-10 | — | — | EP | disclosed |
| WO-2012035423-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-03-22 | — | — | WO | disclosed |