Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.33 |
| ▸ | F9 | P00740 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1693676 | 0.81 | ADORA2A (0.56) | ADORA2AADORA1 | |
| SCHEMBL12467229 | 0.73 | ADORA2A (0.38) | ADORA2AADORA1MAPTPIK3CASMN1; SMN2 | |
| SCHEMBL655151 | 0.68 | EGFR (0.47) | MAPTEGFR | |
| SCHEMBL656145 | 0.66 | FGFR1 (0.56) | EGFR | |
| SCHEMBL654024 | 0.65 | PIK3CA (0.37) | MAPTPIK3CASMN1; SMN2TP53 | |
| SCHEMBL654609 | 0.63 | FGFR1 (0.47) | ADORA2AADORA1MAPTPIK3CAMAPK1 | |
| SCHEMBL653492 | 0.63 | CSNK2A1 (0.48) | EGFR | |
| SCHEMBL20668090 | 0.63 | ALDH1A1 (0.43) | MAPTSMN1; SMN2TP53 | |
| SCHEMBL31045225 | 0.63 | ALDH1A1 (0.43) | MAPTSMN1; SMN2TP53 | |
| SCHEMBL20492668 | 0.63 | FGFR1 (0.45) | PIK3CASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616077-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035423-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-03-22 | — | — | WO | disclosed |