Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24235893 | 1.00 | KMT2A (0.61) | KMT2AHPGDEPHX1EPHX2RAB9A | |
| SCHEMBL14456383 | 1.00 | KMT2A (0.61) | KMT2AHPGDEPHX1EPHX2RAB9A | |
| SCHEMBL14606389 | 1.00 | KMT2A (0.61) | KMT2AHPGDEPHX1EPHX2RAB9A | |
| SCHEMBL23624679 | 1.00 | KMT2A (0.61) | KMT2AHPGDEPHX1EPHX2RAB9A | |
| SCHEMBL2825190 | 1.00 | KMT2A (0.61) | KMT2AHPGDEPHX1EPHX2RAB9A | |
| SCHEMBL967058 | 0.98 | KMT2A (0.57) | KMT2AHPGDEPHX1EPHX2RAB9A | |
| SCHEMBL21378703 | 0.93 | — | — | |
| SCHEMBL2828533 | 0.88 | — | — | |
| SCHEMBL4179001 | 0.79 | KMT2A (0.63) | KMT2AHPGDEPHX1EPHX2RAB9A | |
| SCHEMBL4179368 | 0.79 | KMT2A (0.63) | KMT2AHPGDEPHX1EPHX2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2631238-A1 | Spirocyclic inhibitors of serine proteases for the treatment of hcv infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-08-28 | — | — | EP | disclosed |