Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 13/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | CLK3 | P49761 | 2/20 | 0.43 |
| ▸ | WNT1 | P04628 | 8/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 3/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30356824 | 0.79 | PRKAG1 (0.46) | DYRK1ACSNK2A1AHRGRM5 | |
| SCHEMBL492537 | 0.79 | PRKAG1 (0.46) | DYRK1ACSNK2A1AHRGRM5 | |
| SCHEMBL12480678 | 0.78 | DYRK1A (0.42) | DYRK1ACLK2CLK3WNT1AHR | |
| SCHEMBL29958456 | 0.78 | DYRK1A (0.42) | DYRK1ACLK2CLK3WNT1AHR | |
| SCHEMBL13837149 | 0.78 | KDM4E (0.41) | DYRK1AWNT1AHRGRM5 | |
| Hydrochloric Acid SCHEMBL30645338 | 0.76 | DYRK1A (0.41) | DYRK1ACLK2CLK3WNT1AHR | |
| SCHEMBL16516966 | 0.74 | KDM4E (0.65) | DYRK1ACSNK2A1NPC1 | |
| SCHEMBL492254 | 0.74 | DYRK1A (0.41) | DYRK1ACLK2CLK3WNT1 | |
| SCHEMBL1635357 | 0.73 | AHR (0.43) | DYRK1AWNT1AHRGRM5 | |
| SCHEMBL12468204 | 0.73 | ELANE (0.37) | DYRK1ACLK2CLK3CSNK2A1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619201-A1 | PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2 | Medical Research Council Technology (GB) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038743-A1 | PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2 | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2012-03-29 | — | — | WO | disclosed |