Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.44 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1192148 | 1.00 | SLC18A3 (0.44) | SLC18A3YTHDC1SLC6A2SLC6A4MAPT | |
| SCHEMBL12466177 | 1.00 | SLC18A3 (0.44) | SLC18A3YTHDC1SLC6A2SLC6A4MAPT | |
| SCHEMBL1192262 | 1.00 | SLC18A3 (0.44) | SLC18A3YTHDC1SLC6A2SLC6A4MAPT | |
| SCHEMBL15065296 | 0.81 | YTHDC1 (0.42) | YTHDC1SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL12465971 | 0.81 | YTHDC1 (0.42) | YTHDC1SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL27938356 | 0.81 | YTHDC1 (0.42) | YTHDC1SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL25341885 | 0.80 | YTHDC1 (0.49) | SLC18A3YTHDC1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23583787 | 0.80 | YTHDC1 (0.46) | SLC18A3YTHDC1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL25111999 | 0.80 | YTHDC1 (0.49) | SLC18A3YTHDC1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23329113 | 0.80 | YTHDC1 (0.49) | SLC18A3YTHDC1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668162-A1 | SUBSTITUTED BI-HETEROARYL COMPOUNDS AS CDK9 INHIBITORS AND THEIR USES | Novartis AG (CH) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101066-A1 | PYRIDINE BIARYL AMINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012101065-A2 | PYRIMIDINE BIARYL AMINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012101062-A1 | SUBSTITUTED BI-HETEROARYL COMPOUNDS AS CDK9 INHIBITORS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |