Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 10/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12467348 | 0.92 | SMN1; SMN2 (0.37) | SMN1; SMN2RAB9ANPC1MAPTGAA | |
| SCHEMBL14943210 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2RAB9ANPC1MAPTGAA | |
| SCHEMBL14943216 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2RAB9ANPC1MAPTGAA | |
| SCHEMBL12401672 | 0.82 | SMN1; SMN2 (0.45) | SMN1; SMN2RAB9ANPC1MAPTGAA | |
| SCHEMBL842049 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2RAB9AGAAEPHX1KDM4E | |
| SCHEMBL842048 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2RAB9AGAAEPHX1KDM4E | |
| SCHEMBL12401717 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2RAB9ANPC1MAPTGAA | |
| SCHEMBL8146157 | 0.79 | EPHX1 (0.50) | SMN1; SMN2RAB9ANPC1MAPTGAA | |
| SCHEMBL15219637 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9ANPC1MAPTGAA | |
| SCHEMBL28814747 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9ANPC1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366704-B1 | Inhibitors of serine proteases | VERTEX PHARMA (US) | 2013-10-23 | — | — | EP | disclosed |