Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 5/20 | 0.34 |
| ▸ | CTSB | P07858 | 5/20 | 0.34 |
| ▸ | CTSK | P43235 | 5/20 | 0.34 |
| ▸ | CTSS | P25774 | 4/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12468295 | 0.92 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9AGAANPC1MAPT | |
| SCHEMBL842048 | 0.89 | SMN1; SMN2 (0.40) | SMN1; SMN2RAB9AGAACTSLCTSB | |
| SCHEMBL842049 | 0.89 | SMN1; SMN2 (0.40) | SMN1; SMN2RAB9AGAACTSLCTSB | |
| SCHEMBL13338252 | 0.85 | SMN1; SMN2 (0.38) | SMN1; SMN2RAB9AGAANPC1MAPT | |
| SCHEMBL16328219 | 0.85 | SMN1; SMN2 (0.38) | SMN1; SMN2RAB9AGAANPC1MAPT | |
| SCHEMBL15338725 | 0.83 | SMN1; SMN2 (0.37) | SMN1; SMN2RAB9AGAANPC1MAPT | |
| SCHEMBL11936283 | 0.82 | SMN1; SMN2 (0.39) | SMN1; SMN2RAB9AGAACTSLCTSB | |
| SCHEMBL8236530 | 0.82 | SMN1; SMN2 (0.39) | SMN1; SMN2RAB9AGAACTSLCTSB | |
| SCHEMBL11985580 | 0.81 | CTSB (0.38) | SMN1; SMN2RAB9AGAACTSLCTSB | |
| SCHEMBL8300673 | 0.81 | SMN1; SMN2 (0.39) | SMN1; SMN2RAB9AGAANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366704-B1 | Inhibitors of serine proteases | VERTEX PHARMA (US) | 2013-10-23 | — | — | EP | disclosed |