Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | WEE1 | P30291 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | F2R | P25116 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11412601 | 0.85 | ACLY (0.53) | KDM4EEGFRDPP4 | |
| SCHEMBL6017853 | 0.84 | SMN1; SMN2 (0.53) | LMNASMN1; SMN2GAAHPGDKDM4E | |
| SCHEMBL11402837 | 0.81 | F2RL3 (0.65) | LMNASMN1; SMN2EGFRSRCKMT2A | |
| SCHEMBL11265814 | 0.79 | SMN1; SMN2 (0.51) | LMNASMN1; SMN2GAAHPGDKDM4E | |
| SCHEMBL21500661 | 0.77 | MAP2 (0.47) | LMNASMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL3884447 | 0.74 | EGFR (0.46) | LMNASMN1; SMN2GAAHPGDKDM4E | |
| SCHEMBL27046200 | 0.74 | WEE1 (0.54) | LMNASMN1; SMN2GAAHPGDKDM4E | |
| SCHEMBL8687160 | 0.73 | ACLY (0.62) | KDM4EEGFRKMT2ADPP4 | |
| SCHEMBL11224588 | 0.72 | ACLY (0.54) | KDM4EEGFRKMT2ADPP4 | |
| SCHEMBL8692416 | 0.72 | ACLY (0.54) | LMNASMN1; SMN2KDM4EEGFRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611804-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Forma TM, LLC. (US) | 2013-07-10 | — | — | EP | claimed |
| WO-2012031197-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | FORMA THERAPEUTICS, INC. (US) | 2012-03-08 | — | — | WO | claimed |