Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 7/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 3/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1247277 | 0.92 | SCN9A (0.40) | SCN9ASCN5ANPC1NTRK1MAPT | |
| SCHEMBL1245272 | 0.91 | SCN9A (0.45) | SCN9ASCN5ANPC1NTRK1LPAR1 | |
| SCHEMBL3705536 | 0.87 | LPAR1 (0.51) | LPAR1LPAR2LPAR3MAPT | |
| SCHEMBL1247750 | 0.86 | SCN9A (0.51) | SCN9ASCN5ANTRK1LPAR1LPAR2 | |
| SCHEMBL1246373 | 0.86 | SCN9A (0.40) | SCN9ASCN5ANPC1NTRK1LPAR1 | |
| SCHEMBL1247620 | 0.84 | NTRK1 (0.41) | SCN9ASCN5ANPC1NTRK1MAPT | |
| SCHEMBL1247570 | 0.84 | SCN9A (0.46) | SCN9ASCN5ANPC1NTRK1LPAR1 | |
| SCHEMBL3703083 | 0.84 | LPAR1 (0.47) | LPAR1LPAR2LPAR3 | |
| SCHEMBL1245263 | 0.82 | SCN9A (0.42) | SCN9ASCN5ANPC1NTRK1LPAR1 | |
| SCHEMBL1247626 | 0.82 | SCN9A (0.40) | SCN9ASCN5ANPC1NTRK1LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |