SCHEMBL124692

SCHEMBL124692

O=C(O)c1cc2cc(F)c(N3CC(F)(F)C3)nc2nc1C(F)(F)F

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 2/20 0.32
LMNA P02545 1/20 0.32
CYP2C9 P11712 1/20 0.32
ATP6V1B2 P21281 1/20 0.32
TBXA2R P21731 1/20 0.32
EDNRA P25101 1/20 0.32
TARBP2 Q15633 1/20 0.32
NR1H2 P55055 1/20 0.32
NR1H3 Q13133 1/20 0.32
GFER P55789 1/20 0.31
EPHA2 P29317 1/20 0.30
FLT4 P35916 1/20 0.30
GSK3B P49841 1/20 0.30
RARB P10826 1/20 0.30
TBXAS1 P24557 1/20 0.30
SLC6A3 Q01959 1/20 0.30
SCN10A Q9Y5Y9 1/20 0.30
AKT1 P31749 1/20 0.30
AKT2 P31751 1/20 0.30
AKT3 Q9Y243 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL124782 0.84 ALDH1A1 (0.46)
SCHEMBL124475 0.82 GLA (0.40) CNR2LMNACYP2C9ATP6V1B2TBXA2R
SCHEMBL123588 0.80 ACACB (0.36) LMNANR1H2NR1H3EPHA2FLT4
SCHEMBL125619 0.75 MAPT (0.34) NR1H2NR1H3GFER
SCHEMBL126280 0.74 GFER (0.43) GFER
SCHEMBL126379 0.74 GFER (0.38) NR1H2NR1H3GFER
SCHEMBL125573 0.74 GFER (0.36) NR1H2NR1H3GFER
SCHEMBL3433966 0.72 GFER (0.34) GFER
SCHEMBL122742 0.72 GFER (0.34) GFER
SCHEMBL28008303 0.72 GFER (0.36) GFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8461083-B2 Herbicidal compounds SYNGENTA LIMITED (GB) 2013-06-11 US disclosed
EP-2265120-B1 HERBICIDAL COUMPOUNDS SYNGENTA LTD (GB) 2012-03-07 EP disclosed
CN-102006777-A Herbicidal coumpounds SYNGENTA LTD 2011-04-06 CN disclosed
US-20110021352-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION, INC. (US) 2011-01-27 US disclosed
EP-2265120-A1 HERBICIDAL COUMPOUNDS Syngenta Limited (GB) 2010-12-29 EP disclosed
WO-2009115788-A1 HERBICIDAL COUMPOUNDS SYNGENTA LIMITED (GB) 2009-09-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110021352-A1 HERBICIDAL COMPOUNDS RDX, NQO2, DDT CNR2 1632/4885LMNA 2087/4885CYP2C9 215/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.