Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239658 | 1.00 | KMT2A (0.43) | KMT2AMEN1NPC1RAB9AATM | |
| SCHEMBL240751 | 0.86 | SMN1; SMN2 (0.42) | KMT2AMEN1NPC1KDM1ASMN1; SMN2 | |
| SCHEMBL241050 | 0.85 | MAPT (0.42) | KMT2AMEN1SMN1; SMN2LMNAPOLB | |
| SCHEMBL240492 | 0.82 | KMT2A (0.44) | KMT2AMEN1NPC1KDM1ASMN1; SMN2 | |
| SCHEMBL240689 | 0.82 | ALDH1A1 (0.36) | KMT2AMEN1NPC1SMN1; SMN2LMNA | |
| SCHEMBL240878 | 0.80 | KAT2B (0.42) | KMT2AMEN1NPC1SMN1; SMN2LMNA | |
| SCHEMBL18653275 | 0.79 | ALDH1A1 (0.46) | KMT2AMEN1NPC1KDM1ASMN1; SMN2 | |
| SCHEMBL238882 | 0.79 | KAT2B (0.41) | KMT2AMEN1NPC1SMN1; SMN2LMNA | |
| SCHEMBL810842 | 0.78 | MEN1 (0.53) | KMT2AMEN1NPC1RAB9AATM | |
| SCHEMBL29463873 | 0.78 | MEN1 (0.53) | KMT2AMEN1NPC1RAB9AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678334-A1 | ANTI-VIRAL COMPOUNDS | Abbvie Inc. (US) | 2014-01-01 | — | — | EP | disclosed |
| EP-2627651-A1 | ANTI-VIRAL COMPOUNDS | Abbvie Inc. (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012116257-A1 | ANTI-VIRAL COMPOUNDS | ABBVIE INC. (US) | 2012-08-30 | — | — | WO | disclosed |
| WO-2012051361-A1 | ANTI-VIRAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-04-19 | — | — | WO | disclosed |