Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11565430 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1MAPTRAB9AMEN1 | |
| SCHEMBL30883283 | 0.80 | SMN1; SMN2 (0.69) | SMN1; SMN2NPC1MAPTRAB9AMEN1 | |
| SCHEMBL929698 | 0.80 | GAA (0.54) | SMN1; SMN2NPC1MAPTRAB9AMEN1 | |
| SCHEMBL31399005 | 0.79 | GAA (0.62) | SMN1; SMN2NPC1MAPTRAB9AMEN1 | |
| SCHEMBL929686 | 0.79 | GAA (0.62) | SMN1; SMN2NPC1MAPTRAB9AMEN1 | |
| SCHEMBL1156407 | 0.79 | MAPK1 (0.58) | SMN1; SMN2NPC1MAPTRAB9AMEN1 | |
| SCHEMBL1547622 | 0.79 | TDP1 (0.56) | SMN1; SMN2MAPTTDP1LMNAHPGD | |
| SCHEMBL22866816 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1MAPTRAB9AMEN1 | |
| SCHEMBL29559882 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1MAPTRAB9AMEN1 | |
| SCHEMBL6924992 | 0.77 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1MAPTRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012045729-A1 | IMIDAZO [1, 2 -A] PYRIDINE AND PYRAZOLO [1, 5 -A] PYRIDINE DERIVATIVES AS TRPV1 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-04-12 | — | — | WO | disclosed |