⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367712 | 0.78 | HSP90AA1 (0.31) | — | |
| SCHEMBL11880891 | 0.75 | KDM4E (0.33) | — | |
| SCHEMBL19425888 | 0.75 | APLNR (0.52) | — | |
| SCHEMBL29724050 | 0.73 | SLC6A2 (0.45) | — | |
| SCHEMBL1525815 | 0.73 | SLC6A2 (0.45) | — | |
| SCHEMBL8876690 | 0.70 | — | — | |
| SCHEMBL9640534 | 0.70 | — | — | |
| SCHEMBL1257941 | 0.70 | HSP90AA1 (0.33) | — | |
| SCHEMBL10746544 | 0.70 | — | — | |
| SCHEMBL21042634 | 0.70 | HSP90AA1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137638-B | Bridged nucleic acid GuNA, method for producing same, and intermediate compound | 田边三菱制药株式会社 | 2022-05-03 | — | — | CN | disclosed |
| CN-112996522-A | Bridged artificial nucleic acid ALNA | 田边三菱制药株式会社 | 2021-06-18 | — | — | CN | disclosed |
| EP-2752488-B1 | Antisense design | ROCHE INNOVATION CT COPENHAGEN AS (DK) | 2020-02-12 | — | — | EP | disclosed |
| EP-3222722-B1 | ANTISENSE DESIGN | ROCHE INNOVATION CT COPENHAGEN AS (DK) | 2019-04-10 | — | — | EP | disclosed |
| US-20180237777-A1 | ANTISENSE DESIGN | ROCHE INNOVATION CENTER COPENHAGEN A/S (CH) | 2018-08-23 | — | — | US | disclosed |
| US-20180237778-A1 | ANTISENSE DESIGN | ROCHE INNOVATION CENTER COPENHAGEN A/S (CH) | 2018-08-23 | — | — | US | disclosed |
| US-9994850-B2 | Antisense design | ROCHE INNOVATION CENTER COPENHAGEN A/S (CH) | 2018-06-12 | — | — | US | disclosed |
| CN-108137638-A | Bridging type nucleic acid GuNA, its manufacturing method and midbody compound | 田边三菱制药株式会社 | 2018-06-08 | — | — | CN | disclosed |
| US-9951333-B2 | Antisense design | ROCHE INNOVATION CENTER COPENHAGEN A/S (CH) | 2018-04-24 | — | — | US | disclosed |
| US-9890383-B2 | Antisense design | ROCHE INNOVATION CENTER COPENHAGEN A/S (CH) | 2018-02-13 | — | — | US | disclosed |
| US-4154844-A | ANTIHISTAMINE, GASTRIC JUICE ANTISECRETORY AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-15 | — | — | US | disclosed |
| US-4151288-A | ANTHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-04-24 | — | — | US | disclosed |
| US-4137234-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-01-30 | — | — | US | disclosed |
| US-4137237-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-01-30 | — | — | US | disclosed |
| US-4070475-A | THIOALKYL-, AMINOALKYL-, AND OXYALKYL- SUBSTITUTED GUANIDINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1978-01-24 | — | — | US | disclosed |
| US-4024271-A | INHIBITORS OF HISTAMINE ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-17 | — | — | US | disclosed |
| US-4022797-A | PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-10 | — | — | US | disclosed |
| US-4018931-A | INHIBITION OF H-2 HISTAMINE RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-04-19 | — | — | US | disclosed |
| US-3950333-A | HISTAMINE INHIBITORS, OXYALKYL, THIOALKYL, AMINOALKYL DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-04-13 | — | — | US | disclosed |
| US-3950353-A | HISTAMINE INHIBITORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-04-13 | — | — | US | disclosed |