SCHEMBL1247038

SCHEMBL1247038

OC=CCc1ncccn1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6159661 0.75
SCHEMBL6429020 0.75 HSP90AA1 (0.33)
SCHEMBL1257944 0.75 HSP90AA1 (0.33)
SCHEMBL23037266 0.75 HSP90AA1 (0.33)
SCHEMBL10746552 0.75
SCHEMBL23037268 0.75 HSP90AA1 (0.33)
SCHEMBL8703080 0.73 ALDH1A1 (0.38)
SCHEMBL1525817 0.73 HRH1 (0.45)
SCHEMBL9527267 0.73 HRH1 (0.45)
SCHEMBL27594426 0.71 MAPT (0.45)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108137638-A Bridging type nucleic acid GuNA, its manufacturing method and midbody compound 田边三菱制药株式会社 2018-06-08 CN disclosed
EP-2284269-B1 Antisense design ROCHE INNOVATION CT COPENHAGEN AS (DK) 2017-08-09 EP disclosed
EP-2141233-B1 Antisense design ROCHE INNOVATION CT COPENHAGEN AS (DK) 2016-10-19 EP disclosed
EP-2284269-A2 Antisense design Santaris Pharma A/S (DK) 2011-02-16 EP disclosed
EP-2012799-A2 METABOLICALLY STABLE ALKOXYALKYL ESTERS OF ANTIVIRAL OR ANTIPROLIFERATIVE PHOSPHONATES, NUCLEOSIDE PHOSPHONATES AND NUCLEOSIDE PHOSPHATES Chimerix, Inc. (US) 2009-01-14 EP disclosed
WO-2007130783-A2 METABOLICALLY STABLE ALKOXYALKYL ESTERS OF ANTIVIRAL OR ANTIPROLIFERATIVE PHOSPHONATES, NUCLEOSIDE PHOSPHONATES AND NUCLEOSIDE PHOSPHATES CHIMERIX, INC. (US) 2007-11-15 WO disclosed
EP-1569661-A2 ANTISENSE DESIGN Santaris Pharma A/S (DK) 2005-09-07 EP disclosed
WO-2004046160-A2 AMINO-LNA, THIO-LNA AND ALPHA-L-OXY-LN SANTARIS PHARMA A/S (DK) 2004-06-03 WO disclosed
US-4307101-A ANTIHISTAMINES AND ANTISECRETORY AGENTS OF THE THIOUREA OR UREA DERIVATIVES 5,6,7,8-TETRAHYDROIMIDAZO(1,5A)PYRIDINE SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1981-12-22 US disclosed
US-4293697-A ANTIHISTAMINES SMITH, KLINE & FRENCH LABORATORIES LIMITED (GB) 1981-10-06 US disclosed
US-4154844-A ANTIHISTAMINE, GASTRIC JUICE ANTISECRETORY AGENTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-05-15 US disclosed
US-4151288-A ANTHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-04-24 US disclosed
US-4137234-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-01-30 US disclosed
US-4137237-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-01-30 US disclosed
US-4070475-A THIOALKYL-, AMINOALKYL-, AND OXYALKYL- SUBSTITUTED GUANIDINES SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1978-01-24 US disclosed
US-4024271-A INHIBITORS OF HISTAMINE ACTIVITY SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1977-05-17 US disclosed
US-4022797-A PHARMACEUTICALS SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1977-05-10 US disclosed
US-4018931-A INHIBITION OF H-2 HISTAMINE RECEPTORS SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1977-04-19 US disclosed
US-3950333-A HISTAMINE INHIBITORS, OXYALKYL, THIOALKYL, AMINOALKYL DERIVATIVES SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1976-04-13 US disclosed
US-3950353-A HISTAMINE INHIBITORS SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1976-04-13 US disclosed