Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Linolenic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 7/20 | 0.59 |
| ▸ | PTGS2 known ✓ | P35354 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.59 |
| ▸ | F7 | P08709 | 7/20 | 0.59 |
| ▸ | F3 | P13726 | 7/20 | 0.59 |
| ▸ | PPARG | P37231 | 5/20 | 0.59 |
| ▸ | PPARD | Q03181 | 5/20 | 0.59 |
| ▸ | PPARA | Q07869 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.59 |
| ▸ | OXER1 | Q8TDS5 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | BLM | P54132 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.59 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Linoleic Acid SCHEMBL12471256 | 0.93 | ALDH1A1 (0.59) | ALDH1A1PTGS1F7F3PPARG | |
| Oleic Acid SCHEMBL12470952 | 0.91 | PTGS1 (0.59) | ALDH1A1PTGS1F7F3PPARG | |
| Palmitic Acid SCHEMBL7702151 | 0.83 | PTGS1 (0.69) | ALDH1A1PTGS1PPARGPPARDPPARA | |
| Stearic Acid SCHEMBL12470629 | 0.83 | PTGS1 (0.69) | ALDH1A1PTGS1PPARGPPARDPPARA | |
| Ricinoleic Acid SCHEMBL9559032 | 0.82 | FFAR1 (0.65) | ALDH1A1PTGS1F7F3PPARG | |
| Ibuprofen SCHEMBL3428176 | 0.79 | PTGS1 (0.68) | ALDH1A1PTGS1PTGS2LMNABLM | |
| Ibuprofen SCHEMBL942351 | 0.78 | PTGS1 (0.86) | PTGS1PTGS2LMNABLMAKR1C3 | |
| SCHEMBL23698166 | 0.77 | ALDH1A1 (1.00) | ALDH1A1PTGS1F7F3PPARG | |
| SCHEMBL23698135 | 0.77 | ALDH1A1 (1.00) | ALDH1A1PTGS1F7F3PPARG | |
| SCHEMBL23698246 | 0.77 | ALDH1A1 (1.00) | ALDH1A1PTGS1F7F3PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2673370-A1 | PRODUCTION OF ALCOHOL ESTERS IN SITU USING ALCOHOLS AND FATTY ACIDS PRODUCED BY MICROORGANISMS | E.I. Du Pont De Nemours And Company (US) | 2013-12-18 | — | — | EP | disclosed |
| US-20130040340-A1 | PRODUCTION OF ALCOHOL ESTERS IN SITU USING ALCOHOLS AND FATTY ACIDS PRODUCED BY MICROORGANISMS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2013-02-14 | — | — | US | disclosed |
| WO-2012109221-A1 | PRODUCTION OF ALCOHOL ESTERS IN SITU USING ALCOHOLS AND FATTY ACIDS PRODUCED BY MICROORGANISMS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-08-16 | — | — | WO | disclosed |