Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11901668 | 1.00 | PRMT5 (0.38) | PRMT5BACE1TDP1KMT2APSMB8 | |
| SCHEMBL11964469 | 0.79 | PIK3CD (0.37) | BACE1TDP1KMT2ALMNAKDM4E | |
| Hydrochloric Acid SCHEMBL12472863 | 0.78 | PIK3CD (0.36) | BACE1TDP1KMT2ALMNAGRM2 | |
| Hydrochloric Acid SCHEMBL11901162 | 0.78 | PIK3CD (0.36) | BACE1TDP1KMT2ALMNAGRM2 | |
| SCHEMBL2085938 | 0.76 | SMN1; SMN2 (0.53) | PRMT5BACE1PSMB8SMN1; SMN2NPC1 | |
| SCHEMBL5448072 | 0.76 | PRMT5 (0.64) | PRMT5BACE1PSMB8KDM4ECYP2D6 | |
| SCHEMBL12472807 | 0.75 | CYP11B2 (0.31) | — | |
| SCHEMBL11900583 | 0.75 | CYP11B2 (0.31) | — | |
| SCHEMBL1520483 | 0.73 | SMN1; SMN2 (0.58) | TDP1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL31122306 | 0.73 | GRM2 (0.39) | PRMT5BACE1KMT2APSMB8NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2673269-A1 | HETEROCYCLIC COMPOUNDS AS PI3 KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-12-18 | — | — | EP | disclosed |
| WO-2012107465-A1 | HETEROCYCLIC COMPOUNDS AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-08-16 | — | — | WO | disclosed |