Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.41 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1246325 | 0.90 | SCN9A (0.46) | NTRK1SCN5ASCN9ALPAR1NPSR1 | |
| SCHEMBL1245362 | 0.89 | SCN9A (0.57) | NTRK1SCN5ASCN9ALPAR1NPSR1 | |
| SCHEMBL1245272 | 0.88 | SCN9A (0.45) | NTRK1SCN5ASCN9ALPAR1NPSR1 | |
| SCHEMBL1247418 | 0.88 | LPAR1 (0.48) | NTRK1SCN5ASCN9ALPAR1NPSR1 | |
| SCHEMBL1247325 | 0.86 | NTRK1 (0.57) | NTRK1SCN5ASCN9ALPAR1NPSR1 | |
| SCHEMBL1245178 | 0.86 | SCN9A (0.55) | NTRK1SCN5ASCN9ALPAR1NPSR1 | |
| SCHEMBL2341140 | 0.86 | LPAR1 (0.61) | LPAR1NPSR1LPAR2LPAR3NR1H4 | |
| SCHEMBL1247570 | 0.85 | SCN9A (0.46) | NTRK1SCN5ASCN9ALPAR1NPSR1 | |
| SCHEMBL1247626 | 0.85 | SCN9A (0.40) | NTRK1SCN5ASCN9ALPAR1NPSR1 | |
| SCHEMBL1246481 | 0.84 | SCN9A (0.54) | NTRK1SCN5ASCN9ALPAR1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |