Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.45 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.44 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1247169 | 0.92 | MGLL (0.52) | LPAR1NPSR1ROCK2MGLLSCN9A | |
| SCHEMBL4036879 | 0.90 | NPSR1 (0.56) | NPSR1ROCK2MGLLSCN9ASCN5A | |
| SCHEMBL1246325 | 0.90 | SCN9A (0.46) | LPAR1NPSR1SCN9ASCN5ALPAR2 | |
| SCHEMBL1245255 | 0.90 | LPAR1 (0.43) | LPAR1NPSR1ROCK2MGLLSCN9A | |
| SCHEMBL1245362 | 0.89 | SCN9A (0.57) | LPAR1NPSR1SCN9ASCN5ALPAR2 | |
| SCHEMBL1246454 | 0.89 | NPSR1 (0.48) | NPSR1ROCK2MGLLSCN9ASCN5A | |
| SCHEMBL1245272 | 0.89 | SCN9A (0.45) | LPAR1NPSR1SCN9ASCN5ALPAR2 | |
| SCHEMBL1247342 | 0.88 | SCN9A (0.46) | NPSR1ROCK2MGLLSCN9ASCN5A | |
| SCHEMBL1247351 | 0.88 | NTRK1 (0.45) | LPAR1NPSR1SCN9ASCN5ALPAR2 | |
| SCHEMBL1247293 | 0.88 | SCN9A (0.52) | LPAR1NPSR1SCN9ASCN5ALPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |