Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 7/20 | 0.49 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.49 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1246478 | 0.88 | SCN9A (0.52) | LPAR1LPAR2LPAR3SCN9ASCN5A | |
| SCHEMBL3703837 | 0.88 | LPAR1 (0.62) | LPAR1LPAR2LPAR3SCN9ASCN5A | |
| SCHEMBL11896023 | 0.84 | LPAR1 (0.70) | LPAR1LPAR2LPAR3SCN9ASCN5A | |
| SCHEMBL1247214 | 0.84 | SCN9A (0.56) | LPAR1LPAR2LPAR3SCN9ASCN5A | |
| SCHEMBL1246468 | 0.83 | SCN9A (0.55) | LPAR1LPAR2LPAR3SCN9ASCN5A | |
| SCHEMBL1246287 | 0.82 | SCN9A (0.55) | LPAR1LPAR2LPAR3SCN9ASCN5A | |
| SCHEMBL3707427 | 0.82 | LPAR1 (0.54) | LPAR1LPAR2LPAR3SCN9ASCN5A | |
| SCHEMBL9985320 | 0.82 | LPAR1 (0.70) | LPAR1LPAR2LPAR3SCN9ASCN5A | |
| SCHEMBL1245362 | 0.81 | SCN9A (0.57) | LPAR1LPAR2LPAR3SCN9ASCN5A | |
| SCHEMBL1247143 | 0.80 | SCN9A (0.54) | LPAR1LPAR2LPAR3SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |