Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.63 |
| ▸ | AURKA | O14965 | 8/20 | 0.63 |
| ▸ | CDK4 | P11802 | 5/20 | 0.63 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.63 |
| ▸ | CCND3 | P30281 | 4/20 | 0.63 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.60 |
| ▸ | TTK | P33981 | 2/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.56 |
| ▸ | PLK1 | P53350 | 4/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | BUB1 | O43683 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | ULK1 | O75385 | 1/20 | 0.49 |
| ▸ | STK16 | O75716 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | LATS1 | O95835 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14990502 | 0.92 | CDK2 (0.72) | CDK2CCNA2AURKACDK4CDK6 | |
| SCHEMBL14990344 | 0.88 | CDK2 (0.57) | CDK2CCNA2AURKACDK4CDK6 | |
| SCHEMBL526084 | 0.85 | TTK (0.69) | CDK2CCNA2CCNA1TTKPIM1 | |
| SCHEMBL526461 | 0.84 | TTK (0.69) | CDK2CCNA2CCNA1TTKPIM1 | |
| Potassium SCHEMBL526463 | 0.84 | TTK (0.69) | CDK2CCNA2CCNA1TTKPIM1 | |
| SCHEMBL14990272 | 0.84 | CDK2 (0.53) | CDK2CCNA2AURKACDK4CDK6 | |
| SCHEMBL525847 | 0.83 | CDK2 (0.73) | CDK2CCNA2AURKACDK4CDK6 | |
| SCHEMBL10092911 | 0.82 | PLK1 (0.67) | CDK2CCNA2CCNA1TTKPIM1 | |
| SCHEMBL525992 | 0.79 | CDK2 (0.59) | CDK2CCNA2AURKACDK4CDK6 | |
| SCHEMBL15377682 | 0.78 | TTK (0.85) | CDK2CCNA2AURKACDK4CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598508-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-05 | — | — | EP | claimed |
| WO-2012013557-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-02 | — | — | WO | claimed |