Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 12/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.57 |
| ▸ | CDK4 | P11802 | 5/20 | 0.57 |
| ▸ | CCND3 | P30281 | 5/20 | 0.57 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.57 |
| ▸ | AURKA | O14965 | 5/20 | 0.57 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.56 |
| ▸ | TTK | P33981 | 2/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 3/20 | 0.46 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.46 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL525992 | 0.88 | CDK2 (0.59) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL12473978 | 0.88 | CDK2 (0.63) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL14990502 | 0.87 | CDK2 (0.72) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL525524 | 0.87 | TTK (0.69) | CDK2CCNA2CCNA1TTKPIM1 | |
| SCHEMBL14990266 | 0.86 | CDK2 (0.49) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL18798565 | 0.85 | CDK2 (0.78) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL525963 | 0.84 | PLK1 (0.59) | CDK2CCNA2CCNA1TTKPIM1 | |
| SCHEMBL4163585 | 0.83 | PLK1 (0.57) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL12466621 | 0.81 | CDK2 (0.78) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL15385485 | 0.80 | TTK (0.77) | CDK2CCNA2CDK4CCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9333205-B2 | Isoxazolo-quinazolines as modulators of protein kinase activity | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2016-05-10 | — | — | US | disclosed |
| EP-2598508-B1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES SRL (IT) | 2015-04-22 | — | — | EP | disclosed |
| US-20130143896-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130143896-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | CSNK1A1, RPS6KA1, CSNK2A1 | CDK2 406/4885CCNA2 3027/4885CDK4 718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.