Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 19/20 | 0.66 |
| ▸ | RAF1 | P04049 | 1/20 | 0.66 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12475017 | 0.79 | EPHX2 (1.00) | EPHX2RAF1CA12CA1CA2 | |
| SCHEMBL6049774 | 0.78 | ALDH1A1 (0.46) | — | |
| SCHEMBL5568329 | 0.74 | RAF1 (0.64) | EPHX2RAF1CA12CA1CA2 | |
| SCHEMBL4265602 | 0.74 | NAMPT (0.48) | EPHX2RAF1 | |
| SCHEMBL29614703 | 0.72 | MEN1 (0.45) | — | |
| SCHEMBL12932231 | 0.72 | EPHX2 (1.00) | EPHX2CA12CA1CA2CA9 | |
| SCHEMBL4252286 | 0.72 | MEN1 (0.45) | — | |
| SCHEMBL28408407 | 0.72 | KDM4E (0.39) | — | |
| SCHEMBL4087893 | 0.72 | EPHX2 (0.72) | EPHX2 | |
| SCHEMBL4010827 | 0.72 | EPHX2 (0.85) | EPHX2RAF1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675274-A1 | SORAFENIB DERIVATIVES AS sEH INHIBITORS | The Regents of the University of California (US) | 2013-12-25 | — | — | EP | disclosed |
| WO-2012112570-A1 | SORAFENIB DERIVATIVES AS sEH INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-23 | — | — | WO | disclosed |