Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.49 |
| ▸ | SLC1A5 | Q15758 | 3/20 | 0.48 |
| ▸ | GRM8 | O00222 | 1/20 | 0.45 |
| ▸ | GRM6 | O15303 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12475944 | 1.00 | KIF11 (0.49) | KIF11SLC1A5GRM8GRM6GRM4 | |
| SCHEMBL12475948 | 1.00 | KIF11 (0.49) | KIF11SLC1A5GRM8GRM6GRM4 | |
| SCHEMBL28095117 | 0.97 | KIF11 (0.48) | KIF11SLC1A5GRM8GRM6GRM4 | |
| SCHEMBL15674316 | 0.81 | SLC1A5 (0.43) | KIF11SLC1A5KMT2ASLC6A9POLB | |
| SCHEMBL15674317 | 0.81 | SLC1A5 (0.43) | KIF11SLC1A5KMT2ASLC6A9POLB | |
| SCHEMBL3927386 | 0.81 | SLC6A2 (0.42) | PTGDR2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL3921292 | 0.78 | SLC6A2 (0.39) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL2492138 | 0.77 | SLC6A2 (0.45) | KMT2AMEN1ALDH1A1LMNASLC6A9 | |
| SCHEMBL10419544 | 0.72 | KIF11 (0.53) | KIF11GRM8GRM6GRM4KMT2A | |
| SCHEMBL28463907 | 0.72 | KIF11 (0.53) | KIF11GRM8GRM6GRM4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106117310-B | Small molecule conjugates for intracellular delivery of biologically active compounds | 弗·哈夫曼-拉罗切有限公司 | 2021-04-06 | — | — | CN | disclosed |
| US-9968647-B2 | Small molecule conjugates for intracellular delivery of biologically active compounds | HOFFMANN-LA ROCHE INC. (US) | 2018-05-15 | — | — | US | disclosed |
| EP-3147367-A1 | SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS | F. Hoffmann-La Roche AG (CH) | 2017-03-29 | — | — | EP | disclosed |
| US-20170022505-A1 | SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2017-01-26 | — | — | US | disclosed |
| EP-2658981-B1 | SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS | HOFFMANN LA ROCHE (CH) | 2016-09-28 | — | — | EP | disclosed |
| EP-2658982-B1 | SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2016-04-20 | — | — | EP | disclosed |
| US-9301990-B2 | Small molecule conjugates for intracellular delivery of biologically active compounds | HOFFMANN-LA ROCHE, INC. (US) | 2016-04-05 | — | — | US | disclosed |
| US-9198947-B2 | Small molecule conjugates for intracellular delivery of nucleic acids | HOFFMANN-LA ROCHE INC. (US) | 2015-12-01 | — | — | US | disclosed |
| US-20140135381-A1 | Small molecule conjugates for intracellular delivery of biologically active compounds | HOFFMANN-LA ROCHE INC. (US) | 2014-05-15 | — | — | US | disclosed |
| US-20140135380-A1 | Small molecule conjugates for intracellular delivery of nucleic acids | HOFFMANN-LA ROCHE INC. (US) | 2014-05-15 | — | — | US | disclosed |
| EP-2658981-A1 | SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-06 | — | — | EP | disclosed |
| EP-2658982-A1 | SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-06 | — | — | EP | disclosed |
| WO-2012089602-A1 | SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-05 | — | — | WO | disclosed |
| WO-2012089352-A1 | SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135381-A1 | Small molecule conjugates for intracellular delivery of biologically active compounds | SNRPE, PHAX, SNRPA | KIF11 758/4885SLC1A5 984/4885GRM8 4475/4885 |
| US-20140135380-A1 | Small molecule conjugates for intracellular delivery of nucleic acids | SNRPE, PHAX, SNRPA | KIF11 359/4885SLC1A5 415/4885GRM8 4255/4885 |
| US-20170022505-A1 | SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE COMPOUNDS | SNRPE, PHAX, SNRPA | KIF11 758/4885SLC1A5 984/4885GRM8 4475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.