Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.47 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclooctane SCHEMBL30978275 | 1.00 | TSHR (0.64) | TSHRTHRBLMNACYP1A2SLC22A1 | |
| Cyclohexane SCHEMBL129222 | 1.00 | TSHR (0.64) | TSHRTHRBLMNACYP1A2SLC22A1 | |
| Hexane SCHEMBL5073928 | 1.00 | TSHR (0.64) | TSHRTHRBLMNACYP1A2SLC22A1 | |
| Cyclohexane SCHEMBL10454605 | 1.00 | TSHR (0.64) | TSHRTHRBLMNACYP1A2SLC22A1 | |
| Cyclohexane SCHEMBL5787824 | 1.00 | TSHR (0.64) | TSHRTHRBLMNACYP1A2SLC22A1 | |
| Cyclohexane SCHEMBL10453382 | 1.00 | TSHR (0.64) | TSHRTHRBLMNACYP1A2SLC22A1 | |
| Hexane SCHEMBL18764545 | 1.00 | TSHR (0.64) | TSHRTHRBLMNACYP1A2SLC22A1 | |
| Cyclohexane SCHEMBL11423653 | 1.00 | TSHR (0.64) | TSHRTHRBLMNACYP1A2SLC22A1 | |
| Cyclohexane SCHEMBL10572382 | 1.00 | TSHR (0.64) | TSHRTHRBLMNACYP1A2SLC22A1 | |
| Hexane SCHEMBL7216245 | 1.00 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2658844-B1 | NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS | SANOFI SA (FR) | 2016-10-26 | — | — | EP | disclosed |
| EP-2658844-A1 | NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS | SANOFI (FR) | 2013-11-06 | — | — | EP | disclosed |
| WO-2012089633-A9 | NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS | SANOFI (FR) | 2012-08-23 | — | — | WO | disclosed |
| WO-2012089633-A1 | NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS | SANOFI (FR) | 2012-07-05 | — | — | WO | disclosed |