Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12477239 | 1.00 | MAPT (0.52) | MAPTALDH1A1TDP1HPGDCYP3A4 | |
| SCHEMBL12478319 | 0.85 | ALDH1A1 (0.68) | MAPTALDH1A1TDP1HPGDCYP3A4 | |
| SCHEMBL12478316 | 0.85 | ALDH1A1 (0.68) | MAPTALDH1A1TDP1HPGDCYP3A4 | |
| SCHEMBL12477653 | 0.83 | ALDH1A1 (0.70) | MAPTALDH1A1TDP1HPGDCYP3A4 | |
| SCHEMBL12477655 | 0.83 | ALDH1A1 (0.70) | MAPTALDH1A1TDP1HPGDCYP3A4 | |
| SCHEMBL11761660 | 0.79 | ALDH1A1 (0.51) | MAPTALDH1A1TDP1HPGDCYP3A4 | |
| SCHEMBL11761657 | 0.79 | ALDH1A1 (0.51) | MAPTALDH1A1TDP1HPGDCYP3A4 | |
| SCHEMBL12477670 | 0.79 | ALDH1A1 (0.42) | MAPTALDH1A1TDP1HPGDCYP3A4 | |
| SCHEMBL12477672 | 0.79 | ALDH1A1 (0.42) | MAPTALDH1A1TDP1HPGDCYP3A4 | |
| SCHEMBL12478066 | 0.77 | TRPV1 (0.41) | MAPTALDH1A1TDP1HPGDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170029367-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | CEPHALON INC (US) | 2017-02-02 | — | — | US | claimed |
| US-9475766-B2 | Substituted aromatic sulfur compounds and methods of their use | CEPHALON, INC. (US) | 2016-10-25 | — | — | US | claimed |
| US-20140005175-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | CEPHALON, INC. (US) | 2014-01-02 | — | — | US | claimed |
| WO-2012116151-A2 | SUBSTITUTED AROMATIC SULFUR COMPOUNDS AND METHODS OF THEIR USE | CEPHALON, INC. (US) | 2012-08-30 | — | — | WO | claimed |
| US-20170029367-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | CEPHALON INC (US) | 2017-02-02 | — | — | US | disclosed |
| US-20170029367-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | CEPHALON INC (US) | 2017-02-02 | — | — | US | disclosed |
| US-20170029367-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | CEPHALON INC (US) | 2017-02-02 | — | — | US | disclosed |
| US-9475766-B2 | Substituted aromatic sulfur compounds and methods of their use | CEPHALON, INC. (US) | 2016-10-25 | — | — | US | disclosed |
| US-9475766-B2 | Substituted aromatic sulfur compounds and methods of their use | CEPHALON, INC. (US) | 2016-10-25 | — | — | US | disclosed |
| US-9475766-B2 | Substituted aromatic sulfur compounds and methods of their use | CEPHALON, INC. (US) | 2016-10-25 | — | — | US | disclosed |
| US-20140005175-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | CEPHALON, INC. (US) | 2014-01-02 | — | — | US | disclosed |
| WO-2012116151-A2 | SUBSTITUTED AROMATIC SULFUR COMPOUNDS AND METHODS OF THEIR USE | CEPHALON, INC. (US) | 2012-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140005175-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | RB1, NRAS, TP53 | MAPT 4091/4885ALDH1A1 227/4885TDP1 3658/4885 |
| US-20170029367-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | RB1, NRAS, TP53 | MAPT 4091/4885ALDH1A1 227/4885TDP1 3658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.