Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.58 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12477753 | 1.00 | ALDH1A1 (0.58) | ALDH1A1MAPTHPGDTDP1NPC1 | |
| SCHEMBL12477338 | 0.89 | ALDH1A1 (0.56) | ALDH1A1MAPTHPGDTDP1NPC1 | |
| SCHEMBL12477333 | 0.89 | ALDH1A1 (0.56) | ALDH1A1MAPTHPGDTDP1NPC1 | |
| SCHEMBL12477377 | 0.88 | ALDH1A1 (0.55) | ALDH1A1MAPTHPGDTDP1NPC1 | |
| SCHEMBL12477371 | 0.88 | ALDH1A1 (0.55) | ALDH1A1MAPTHPGDTDP1NPC1 | |
| SCHEMBL15400868 | 0.82 | MAPT (0.50) | ALDH1A1MAPTHPGDTDP1NPC1 | |
| SCHEMBL15400867 | 0.82 | MAPT (0.50) | ALDH1A1MAPTHPGDTDP1NPC1 | |
| SCHEMBL27947254 | 0.80 | ALDH1A1 (0.39) | ALDH1A1MAPTHPGDTDP1NPC1 | |
| SCHEMBL12477653 | 0.79 | ALDH1A1 (0.70) | ALDH1A1MAPTHPGDTDP1NPC1 | |
| SCHEMBL12477655 | 0.79 | ALDH1A1 (0.70) | ALDH1A1MAPTHPGDTDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170029367-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | CEPHALON INC (US) | 2017-02-02 | — | — | US | claimed |
| US-9475766-B2 | Substituted aromatic sulfur compounds and methods of their use | CEPHALON, INC. (US) | 2016-10-25 | — | — | US | claimed |
| CN-103476752-B | Substituted aromatic series sulphur compound and using method thereof | 赛福伦公司 | 2016-09-28 | — | — | CN | claimed |
| US-20140005175-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | CEPHALON, INC. (US) | 2014-01-02 | — | — | US | claimed |
| US-20170029367-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | CEPHALON INC (US) | 2017-02-02 | — | — | US | disclosed |
| US-20170029367-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | CEPHALON INC (US) | 2017-02-02 | — | — | US | disclosed |
| US-20170029367-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | CEPHALON INC (US) | 2017-02-02 | — | — | US | disclosed |
| US-9475766-B2 | Substituted aromatic sulfur compounds and methods of their use | CEPHALON, INC. (US) | 2016-10-25 | — | — | US | disclosed |
| US-9475766-B2 | Substituted aromatic sulfur compounds and methods of their use | CEPHALON, INC. (US) | 2016-10-25 | — | — | US | disclosed |
| US-9475766-B2 | Substituted aromatic sulfur compounds and methods of their use | CEPHALON, INC. (US) | 2016-10-25 | — | — | US | disclosed |
| CN-103476752-B | Substituted aromatic series sulphur compound and using method thereof | 赛福伦公司 | 2016-09-28 | — | — | CN | disclosed |
| US-20140005175-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | CEPHALON, INC. (US) | 2014-01-02 | — | — | US | disclosed |
| WO-2012116151-A2 | SUBSTITUTED AROMATIC SULFUR COMPOUNDS AND METHODS OF THEIR USE | CEPHALON, INC. (US) | 2012-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140005175-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | RB1, NRAS, TP53 | ALDH1A1 227/4885MAPT 4091/4885HPGD 942/4885 |
| US-20170029367-A1 | Substituted Aromatic Sulfur Compounds and Methods of Their Use | RB1, NRAS, TP53 | ALDH1A1 227/4885MAPT 4091/4885HPGD 942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.