SCHEMBL12484261

SCHEMBL12484261

NCc1ccc(OC2CCN(C3CCC3)CC2)cc1

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 20/20 0.57
KCNH2 Q12809 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16702147 0.85 HRH3 (0.57) HRH3KCNH2
SCHEMBL2821556 0.85 HRH3 (0.57) HRH3KCNH2
SCHEMBL737639 0.84 HRH3 (0.63) HRH3KCNH2
SCHEMBL2819889 0.82 HRH3 (0.55) HRH3
SCHEMBL4464014 0.81 HRH3 (0.68) HRH3KCNH2
SCHEMBL4221612 0.80 HRH3 (0.52) HRH3KCNH2
SCHEMBL3272606 0.80 HRH3 (0.57) HRH3
SCHEMBL508364 0.80 CSNK2A1 (0.56) HRH3
SCHEMBL17533980 0.80 HRH3 (0.58) HRH3KCNH2
SCHEMBL5019001 0.80 ST14 (0.48) HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2694492-B1 NOVEL COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGANDS SUVEN LIFE SCIENCES LTD (IN) 2015-07-29 EP disclosed
US-9079888-B2 Compounds as histamine H3 receptor ligands SUVEN LIFE SCIENCES LIMITED (IN) 2015-07-14 US disclosed
US-20140135304-A1 NOVEL COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGANDS SUVEN LIFE SCIENCES LIMITED (IN) 2014-05-15 US disclosed
EP-2694492-A1 NOVEL COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGANDS Suven Life Sciences Limited (IN) 2014-02-12 EP disclosed
WO-2012114348-A1 NOVEL COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGANDS SUVEN LIFE SCIENCES LIMITED (IN) 2012-08-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140135304-A1 NOVEL COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGANDS HRH3, HRH4, HRH1 HRH3 1/4885KCNH2 643/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.