Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | ALAD | P13716 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12483996 | 0.83 | KDM4E (0.43) | NPC1RAB9AKDM4ELMNAMAPT | |
| SCHEMBL12483757 | 0.83 | CHRNA7 (0.46) | LMNAMAPTABCB11PTGS2GABRA2 | |
| SCHEMBL14226131 | 0.83 | GSK3B (0.42) | NPC1RAB9AKDM4ELMNAMAPT | |
| SCHEMBL15894871 | 0.81 | CHRNA7 (0.41) | RAB9ALMNAMAPTSMN1; SMN2CNR1 | |
| SCHEMBL1260378 | 0.79 | CNR1 (0.49) | CNR1POLBKMT2AMEN1CYP2C9 | |
| SCHEMBL1260411 | 0.78 | CNR1 (0.43) | RHEBKDM5AKDM4CKDM5BMCL1 | |
| SCHEMBL16402810 | 0.78 | CHRNA7 (0.52) | KDM4CCNR1 | |
| SCHEMBL23524515 | 0.77 | SMN1; SMN2 (0.49) | NPC1LMNASMN1; SMN2CNR1KMT2A | |
| SCHEMBL1259826 | 0.76 | CYP2C9 (0.42) | RHEBKDM5AKDM4CKDM5BMCL1 | |
| SCHEMBL13832762 | 0.76 | USP14 (0.50) | NPC1SMN1; SMN2CNR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678327-A1 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | Lupin Limited (IN) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012114285-A9 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | LUPIN LIMITED (IN) | 2012-10-18 | — | — | WO | disclosed |
| WO-2012114285-A1 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | LUPIN LIMITED (IN) | 2012-08-30 | — | — | WO | disclosed |