USP14 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL13740012	1.00	20/20
SCHEMBL13741172	1.00	20/20
SCHEMBL14152404	1.00	20/20
SCHEMBL13739913	0.57	19/20
SCHEMBL5171243	0.63	18/20
SCHEMBL6921647	0.62	18/20
SCHEMBL13740123	0.57	18/20
SCHEMBL6923922	0.48	18/20
SCHEMBL14708800	0.46	18/20
SCHEMBL13832704	0.62	15/20
SCHEMBL14409138	0.57	14/20
SCHEMBL4057298	0.54	14/20
SCHEMBL11620900	0.48	14/20
SCHEMBL13832862	0.61	13/20
SCHEMBL13739768	0.60	13/20
SCHEMBL13832852	0.56	13/20
SCHEMBL13832762	0.50	13/20
SCHEMBL1664057	0.40	13/20
SCHEMBL13832714	0.69	12/20
SCHEMBL14226097	0.65	12/20

Clinical trials — most relevant to USP14 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors on Sarcopenia in Hemodialysis Patients	PHASE4	NOT_YET_RECRUITING
Efficacy and Safety of Drug Combination Therapy of Isotretinoin and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19	PHASE2	UNKNOWN
Relapsed and/or Refractory Non-Hodgkin Lymphoma Study	PHASE2	WITHDRAWN
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes	PHASE2	UNKNOWN
Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma	PHASE2	WITHDRAWN
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers	PHASE2	NOT_YET_RECRUITING
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
Studying TAK-243 in Patients With Advanced Cancer	PHASE1	RECRUITING
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Role of USP35 in the Detection of Ferroptosis in Juvenile Autoimmune Hepatitis	nan	NOT_YET_RECRUITING
Clinical Trial of Levodopa/Carbidopa ( Sinemet) Therapy in Angel Man Syndrome	nan	COMPLETED
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome	nan	RECRUITING
Relationship Between Nutritional State and Respiratory Muscle Weakness in Adult Patients With Bronchietasis	nan	UNKNOWN
Inhibition of SENP1 for the Suppression of OS Growth and Metastasis	nan	UNKNOWN
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure	nan	COMPLETED
Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma	nan	COMPLETED
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1	nan	RECRUITING
Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas	nan	RECRUITING
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
The PREServation of MUScle Function in Critically Ill Patients (PRESMUS)	nan	UNKNOWN
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors	nan	NOT_YET_RECRUITING
Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome	nan	ACTIVE_NOT_RECRUITING
Establishment of a Prospective Clinical-biological Database	nan	RECRUITING
The Role of RING Ubiquitin Ligases in Biologic and Oncologic Processes in Tissues of Mesenchymal Origin	nan	UNKNOWN
Evaluation of Prognostic Factors: From Breast Cancer to Bone Metastases	nan	UNKNOWN
Low Dose Melphalan and Bortezomib for AML and High-Risk MDS	nan	COMPLETED
Exercise Therapy to Reduce Heart Failure Symptoms; Sorting Mechanisms of Benefit	nan	COMPLETED
Genetic Variation in TRAF3IP2 (rs13190932)	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a USP14 binder may also engage these)

Protein	Name	Similarity
P40826	—	1.000	P40826 →
P60051	—	1.000	P60051 →
Q0IIF7	—	1.000	Q0IIF7 →
Q9JMA1	—	1.000	Q9JMA1 →
Q84WC6	—	0.997	Q84WC6 →
Q92353	—	0.995	Q92353 →
E1BMF7	—	0.993	E1BMF7 →
Q949Y0	—	0.992	Q949Y0 →
Q17361	—	0.990	Q17361 →
USP13	Ubiquitin carboxyl-terminal hydrolase 13	0.989	landscape →
Q4VSI4	—	0.988	Q4VSI4 →
Q5BKP2	—	0.988	Q5BKP2 →
P43593	—	0.987	P43593 →
E1BY77	—	0.987	E1BY77 →
F6V6I0	—	0.987	F6V6I0 →
USP7	Ubiquitin carboxyl-terminal hydrolase 7	0.986	landscape →
F1QFS9	—	0.985	F1QFS9 →
Q6U7I1	—	0.984	Q6U7I1 →
Q09879	—	0.983	Q09879 →
Q9UTT1	—	0.983	Q9UTT1 →
Q8L6Y1	—	0.983	Q8L6Y1 →
Q86UV5	—	0.982	Q86UV5 →
Q6A4J8	—	0.981	Q6A4J8 →
B2GUZ1	—	0.981	B2GUZ1 →
P54201	—	0.980	P54201 →
Q9C585	—	0.980	Q9C585 →
Q9VYQ8	—	0.980	Q9VYQ8 →
Q76LT8	—	0.980	Q76LT8 →
Q3V0C5	—	0.980	Q3V0C5 →
A6QR55	—	0.980	A6QR55 →