Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 5/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12486706 | 1.00 | PRMT5 (0.49) | PRMT5WDR77HDAC6USP2KMT2A | |
| SCHEMBL12486445 | 0.87 | USP2 (0.46) | PRMT5WDR77HDAC6USP2KMT2A | |
| SCHEMBL12486439 | 0.87 | USP2 (0.46) | PRMT5WDR77HDAC6USP2KMT2A | |
| SCHEMBL12486651 | 0.78 | HDAC6 (0.54) | PRMT5WDR77HDAC6KMT2AMAPT | |
| SCHEMBL12486652 | 0.78 | HDAC6 (0.54) | PRMT5WDR77HDAC6KMT2AMAPT | |
| SCHEMBL12486905 | 0.78 | HDAC6 (0.52) | PRMT5WDR77HDAC6KMT2AMAPT | |
| SCHEMBL12486907 | 0.78 | HDAC6 (0.52) | PRMT5WDR77HDAC6KMT2AMAPT | |
| SCHEMBL12487063 | 0.77 | RAB9A (0.42) | HDAC6USP2KMT2AMAPTALDH1A1 | |
| SCHEMBL12487066 | 0.77 | RAB9A (0.42) | HDAC6USP2KMT2AMAPTALDH1A1 | |
| SCHEMBL12684643 | 0.77 | RAB9A (0.42) | HDAC6USP2KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012117421-A1 | HISTONE DEACETYLASE INHIBITORS | ORCHID RESEARCH LABORATORIES LTD (IN) | 2012-09-07 | — | — | WO | claimed |
| WO-2012117421-A1 | HISTONE DEACETYLASE INHIBITORS | ORCHID RESEARCH LABORATORIES LTD (IN) | 2012-09-07 | — | — | WO | disclosed |