Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | NQO2 | P16083 | 2/20 | 0.50 |
| ▸ | NQO1 | P15559 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12487118 | 1.00 | TLR9 (0.58) | TLR9MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL28111449 | 0.86 | NQO2 (0.64) | MEN1KMT2AMAPTLMNANQO2 | |
| SCHEMBL12487052 | 0.82 | MAPT (0.56) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL10389445 | 0.82 | NQO2 (0.60) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL10389790 | 0.82 | NQO2 (0.60) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL12487051 | 0.82 | MAPT (0.56) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL1773028 | 0.82 | NQO2 (0.60) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL10389789 | 0.82 | NQO2 (0.60) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL11833187 | 0.81 | MAPT (0.59) | MEN1KMT2AMAPTSMN1; SMN2NQO2 | |
| SCHEMBL19436965 | 0.80 | TLR9 (0.59) | TLR9MEN1KMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9295754-B2 | Noggin inhibitory compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2016-03-29 | — | — | US | claimed |
| EP-2678050-B1 | NOGGIN BLOCKING COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | UNIV EMORY (US) | 2020-10-14 | — | — | EP | disclosed |
| US-9295754-B2 | Noggin inhibitory compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2016-03-29 | — | — | US | disclosed |
| US-20130337082-A1 | NOGGIN INHIBITORY COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2013-12-19 | — | — | US | disclosed |
| WO-2012116135-A9 | NOGGIN BLOCKING COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2013-01-10 | — | — | WO | disclosed |
| WO-2012116135-A2 | NOGGIN BLOCKING COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2012-08-30 | — | — | WO | disclosed |