Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | JAK2 | O60674 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14827625 | 0.96 | NPC1 (0.69) | NPC1KMT2AMEN1JAK2LMNA | |
| SCHEMBL13571874 | 0.89 | ALDH1A1 (0.55) | NPC1KMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL14664047 | 0.88 | NPC1 (0.59) | NPC1KMT2AMEN1JAK2LMNA | |
| SCHEMBL13571396 | 0.86 | HSD17B10 (0.54) | NPC1KMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL13571484 | 0.86 | HSD17B10 (0.54) | NPC1KMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL17474759 | 0.85 | NPC1 (0.80) | NPC1KMT2AMEN1JAK2LMNA | |
| SCHEMBL17474788 | 0.85 | NPC1 (0.80) | NPC1KMT2AMEN1JAK2LMNA | |
| SCHEMBL12488603 | 0.85 | NPC1 (0.72) | NPC1KMT2AMEN1JAK2LMNA | |
| SCHEMBL12489106 | 0.84 | NPC1 (0.63) | NPC1KMT2AMEN1JAK2LMNA | |
| SCHEMBL1752680 | 0.84 | NPC1 (0.74) | NPC1KMT2AMEN1JAK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011082077-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-07-07 | — | — | WO | disclosed |