Sugi Predict

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SCHEMBL12488258

SCHEMBL12488258

COCc1nnc(-c2cc(C(=O)OC)c(C3CC3)cc2C)[nH]1

nearest known ligand 0.42

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ FASN P49327 16/20 0.42
▸ PDK2 Q15119 1/20 0.40
▸ PDK4 Q16654 1/20 0.40
▸ SLC6A3 Q01959 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ RXFP1 Q9HBX9 1/20 0.34
▸ LMNA P02545 1/20 0.32
▸ POLB P06746 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12488251 0.90 FASN (0.42) FASNPDK2PDK4
SCHEMBL12488183 0.80 MAPT (0.36) FASNKDM4EMAPTRXFP1LMNA
SCHEMBL12489180 0.77 FASN (0.42) FASN
SCHEMBL12488288 0.77 FASN (0.42) FASNPDK2PDK4
SCHEMBL30409619 0.76 FASN (0.58) FASN
SCHEMBL12489408 0.76 FASN (0.75) FASN
SCHEMBL15555190 0.75 PDK2 (0.41) FASNPDK2PDK4SLC6A3
SCHEMBL13470626 0.74 FASN (0.57) FASN
SCHEMBL30281049 0.73 FASN (0.55) FASN
SCHEMBL12489054 0.73 FASN (0.41) FASNPDK2PDK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12551490-B2 Heterocyclic modulators of lipid synthesis SAGIMET BIOSCIENCES INC. (US) 2026-02-17 — — US disclosed
US-20240400552-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS SAGIMET BIOSCIENCES INC. 2024-12-05 — — US disclosed
US-20230405016-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS SAGIMET BIOSCIENCES INC. 2023-12-21 — — US disclosed
CN-116139138-A Heterocyclic modulators of lipid synthesis 3-V生物科学股份有限公司 2023-05-23 — — CN disclosed
US-11622968-B2 Heterocyclic modulators of lipid synthesis SAGIMET BIOSCIENCES INC. (US) 2023-04-11 — — US disclosed
CN-110177551-B Heterocyclic modulators of lipid synthesis 3-V生物科学股份有限公司 2023-02-17 — — CN disclosed
US-20220340556-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS SAGIMET BIOSCIENCES INC. 2022-10-27 — — US disclosed
US-20220296605-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS SAGIMET BIOSCIENCES INC. 2022-09-22 — — US disclosed
US-20220296605-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS SAGIMET BIOSCIENCES INC. 2022-09-22 — — US disclosed
US-11034690-B2 Heterocyclic modulators of lipid synthesis Saginiet Biosciences Inc. (US) 2021-06-15 — — US disclosed
US-20140322355-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS 3-V BIOSCIENCES, INC. (US) 2014-10-30 — — US disclosed
US-8871790-B2 Heterocyclic modulators of lipid synthesis 3-V BIOSCIENCES, INC. (US) 2014-10-28 — — US disclosed
US-8871790-B2 Heterocyclic modulators of lipid synthesis 3-V BIOSCIENCES, INC. (US) 2014-10-28 — — US disclosed
US-8871790-B2 Heterocyclic modulators of lipid synthesis 3-V BIOSCIENCES, INC. (US) 2014-10-28 — — US disclosed
EP-2683244-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS 3-V Biosciences, Inc. (US) 2014-01-15 — — EP disclosed
US-20120264737-A1 Heterocyclic Modulators of Lipid Synthesis 3-V BIOSCIENCES, INC. (US) 2012-10-18 — — US disclosed
US-20120264737-A1 Heterocyclic Modulators of Lipid Synthesis 3-V BIOSCIENCES, INC. (US) 2012-10-18 — — US disclosed
US-20120264737-A1 Heterocyclic Modulators of Lipid Synthesis 3-V BIOSCIENCES, INC. (US) 2012-10-18 — — US disclosed
WO-2012122391-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS 3-V BIOSCIENCES, INC. (US) 2012-09-13 — — WO disclosed
WO-2012122391-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS 3-V BIOSCIENCES, INC. (US) 2012-09-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220340556-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FASN, FADS1, FADS2 FASN 1/4885PDK2 314/4885PDK4 271/4885
US-20120264737-A1 Heterocyclic Modulators of Lipid Synthesis FASN, FADS1, FADS2 FASN 1/4885PDK2 281/4885PDK4 261/4885
US-20140322355-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FASN, FADS1, FADS2 FASN 1/4885PDK2 281/4885PDK4 261/4885
US-20230405016-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FASN, FADS1, FADS2 FASN 1/4885PDK2 243/4885PDK4 223/4885
US-20240400552-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FASN, FADS1, FADS2 FASN 1/4885PDK2 314/4885PDK4 271/4885
US-11034690-B2 Heterocyclic modulators of lipid synthesis FASN, FADS1, SCD FASN 1/4885PDK2 233/4885PDK4 211/4885
US-20220296605-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FASN, FADS1, SCD FASN 1/4885PDK2 233/4885PDK4 211/4885
US-12551490-B2 Heterocyclic modulators of lipid synthesis FASN, FADS1, FADS2 FASN 1/4885PDK2 1856/4885PDK4 1237/4885
US-11622968-B2 Heterocyclic modulators of lipid synthesis FASN, FADS1, SCD FASN 1/4885PDK2 233/4885PDK4 211/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.