Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 6/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.43 |
| ▸ | PAK4 | O96013 | 10/20 | 0.43 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.36 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.36 |
| ▸ | PAK6 | Q9NQU5 | 1/20 | 0.36 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.36 |
| ▸ | TTBK1 | Q5TCY1 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11971090 | 0.79 | PAK4 (0.58) | MAP3K14PRKD1PAK4 | |
| SCHEMBL11971208 | 0.72 | MAP3K14 (0.46) | MAP3K14 | |
| SCHEMBL12001744 | 0.70 | PAK4 (0.39) | MAP3K14PRKD1PAK4PAK1PKN1 | |
| SCHEMBL11970785 | 0.70 | PAK4 (0.58) | MAP3K14PRKD1PAK4PIKFYVEPAK1 | |
| SCHEMBL11971316 | 0.69 | PAK4 (0.46) | MAP3K14PRKD1PAK4PIKFYVE | |
| SCHEMBL11970928 | 0.67 | MAP3K14 (0.59) | MAP3K14 | |
| SCHEMBL11970796 | 0.67 | PAK4 (0.61) | MAP3K14PRKD1PAK4PIKFYVEPAK1 | |
| SCHEMBL11970772 | 0.67 | MAP3K14 (0.57) | MAP3K14PRKD1PAK4PIKFYVEPAK1 | |
| SCHEMBL11970498 | 0.64 | MAP3K14 (0.55) | MAP3K14PRKD1PAK4PIKFYVEPAK1 | |
| SCHEMBL11970794 | 0.64 | PAK4 (0.58) | MAP3K14PRKD1PAK4PIKFYVEPAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2686314-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | F.HOFFMANN-LA ROCHE AG (CH) | 2014-01-22 | — | — | EP | disclosed |
| WO-2012123522-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-20 | — | — | WO | disclosed |