Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 5/20 | 0.39 |
| ▸ | MAP3K14 | Q99558 | 8/20 | 0.38 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.30 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.30 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.30 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.30 |
| ▸ | PAK6 | Q9NQU5 | 1/20 | 0.30 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11971090 | 0.85 | PAK4 (0.58) | PAK4MAP3K14PRKD1 | |
| SCHEMBL12001706 | 0.82 | MAP3K14 (0.38) | PAK4MAP3K14ALDH1A1TSHRTTBK1 | |
| SCHEMBL12001727 | 0.79 | MAP3K14 (0.42) | PAK4MAP3K14PRKD1TTBK1 | |
| SCHEMBL12001509 | 0.79 | MAP3K14 (0.57) | PAK4MAP3K14PRKD1TTBK1PAK1 | |
| SCHEMBL12001579 | 0.78 | MAP3K14 (0.48) | PAK4MAP3K14PRKD1TTBK1PAK1 | |
| SCHEMBL12001630 | 0.77 | MAP3K14 (0.42) | PAK4MAP3K14PRKD1TTBK1PAK1 | |
| SCHEMBL12001718 | 0.77 | MAP3K14 (0.47) | PAK4MAP3K14PRKD1TTBK1PAK1 | |
| SCHEMBL12001798 | 0.77 | MAP3K14 (0.47) | PAK4MAP3K14PRKD1TTBK1PAK1 | |
| SCHEMBL11971208 | 0.77 | MAP3K14 (0.46) | MAP3K14PDE4BPDE4DALDH1A1 | |
| SCHEMBL12001570 | 0.77 | MAP3K14 (0.51) | MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | GENENTECH, INC. (US) | 2012-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | NFKB1, NFRKB, NFKBIA | PAK4 1856/4885MAP3K14 519/4885PRKD1 1505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.