Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14735229 | 0.83 | LMNA (0.44) | ACE2LMNAMAPK1HTTRAB9A | |
| SCHEMBL2627846 | 0.82 | ACE2 (0.56) | ACE2LMNAMAPK1HTTRAB9A | |
| SCHEMBL23896809 | 0.81 | LMNA (0.51) | ACE2LMNAMAPK1HTTRAB9A | |
| SCHEMBL20768576 | 0.80 | GRM1 (0.45) | ACE2LMNAMAPK1HTTRAB9A | |
| SCHEMBL20768577 | 0.80 | GRM1 (0.45) | ACE2LMNAMAPK1HTTRAB9A | |
| SCHEMBL12584011 | 0.79 | GRM1 (0.51) | ACE2LMNAMAPK1HTTRAB9A | |
| SCHEMBL27822624 | 0.79 | LMNA (0.50) | ACE2LMNAMAPK1HTTRAB9A | |
| SCHEMBL3649293 | 0.79 | GRM1 (0.51) | ACE2LMNAMAPK1HTTRAB9A | |
| SCHEMBL20178624 | 0.79 | RARB (0.51) | RARBTSHR | |
| Hydrochloric Acid SCHEMBL20539066 | 0.78 | GRM1 (0.50) | ACE2LMNAMAPK1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2804868-A1 | PYRAN-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2014-11-26 | — | — | EP | disclosed |
| EP-2686325-A1 | MORPHOLINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2014-01-22 | — | — | EP | disclosed |
| WO-2013109521-A1 | PYRAN-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-25 | — | — | WO | disclosed |
| WO-2012125613-A1 | MORPHOLINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-09-20 | — | — | WO | disclosed |