SCHEMBL12493473

SCHEMBL12493473

NS(=O)(=O)CCc1cccc(Br)c1

nearest known ligand 0.58

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ TAAR1 Q96RJ0 3/20 0.58
▸ CA2 P00918 3/20 0.51
▸ CA1 P00915 2/20 0.51
▸ CA9 Q16790 2/20 0.51
▸ CA12 O43570 1/20 0.51
▸ IDO1 P14902 2/20 0.47
▸ AGXT P21549 2/20 0.47
▸ RECQL P46063 1/20 0.47
▸ CA5A P35218 1/20 0.42
▸ BACE1 P56817 1/20 0.41
▸ EGFR P00533 2/20 0.41
▸ ERBB2 P04626 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1371390 0.85 TAAR1 (0.57) TAAR1CA2CA1CA9CA12
SCHEMBL23703162 0.81 TAAR1 (0.53) TAAR1IDO1AGXTEGFRERBB2
SCHEMBL4871516 0.81 TAAR1 (0.53) TAAR1CA2CA1CA9CA12
SCHEMBL1118907 0.81 CA1 (0.57) TAAR1CA2CA1CA9CA12
SCHEMBL1641618 0.79 RECQL (0.58) CA2CA1CA9CA12RECQL
SCHEMBL23733099 0.79 TAAR1 (0.50) TAAR1IDO1AGXTBACE1EGFR
SCHEMBL7659779 0.78 TAAR1 (0.58) TAAR1CA2IDO1RECQL
SCHEMBL4878820 0.78 TAAR1 (0.58) TAAR1IDO1AGXTRECQLBACE1
SCHEMBL4881416 0.78 TAAR1 (0.58) TAAR1CA2CA1CA12IDO1
SCHEMBL23732878 0.77 TAAR1 (0.57) TAAR1CA2CA1CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12195490-B2 STRAD-binding agents and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-01-14 — — US disclosed
CN-115916966-A STRAD binding agents and uses thereof 加利福尼亚大学董事会 2023-04-04 — — CN disclosed
EP-4097223-A1 STRAD-BINDING AGENTS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-12-07 — — EP disclosed
WO-2021155004-A1 STRAD-BINDING AGENTS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-08-05 — — WO disclosed
WO-2021155004-A1 STRAD-BINDING AGENTS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-08-05 — — WO disclosed
CN-107922362-A 1,3, 4-oxadiazole sulfonamide derivative compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions containing the same 株式会社钟根堂 2018-04-17 — — CN disclosed
EP-2683703-A1 NOVEL SUBSTITUTED PHENYL-OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, DRUGS CONTAINING SAID COMPOUNDS AND THE USE THEREOF SANOFI (FR) 2014-01-15 — — EP disclosed
WO-2012120057-A1 NOVEL SUBSTITUTED PHENYL-OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, DRUGS CONTAINING SAID COMPOUNDS AND THE USE THEREOF SANOFI (FR) 2012-09-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12195490-B2 STRAD-binding agents and uses thereof STRAP, STRA6, PLAUR TAAR1 4465/4885CA2 2899/4885CA1 3508/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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